If you know someone who has schizophrenia and is displaying negative symptoms, including a lack of drive and motivation and limited interaction with others, learn about this research study evaluating an investigational drug for negative symptoms of schizophrenia (NSS).

About This Study: 

This research study is evaluating an oral investigational drug when it is given to participants experiencing negative symptoms of schizophrenia. Study doctors want to compare the effects of the investigational drug to placebo, which is an inactive substance that looks like the investigational drug.

Participants will be randomly assigned (like the flip of a coin) to receive either the investigational drug or placebo. Participants have an equal chance of being assigned to receive either study drug (investigational or placebo).

No one will know the study drug assignments. However, in the event of an emergency, this information can be provided to the study doctor.

Participants will take their study drug twice a day for approximately 15 weeks. Total study participation will last about 23 weeks.

Study participation includes seven visits to the study center and six phone calls from the study staff. At study center visits, the study doctor and study staff will evaluate participants’ health and response to their study drug.

All study participants will need an informant to answer questions about them. The informant should be someone who knows the participant, such as a family member, close friend, group home manager, or case worker.

Additionally, participants may be allowed to continue taking their current schizophrenia medication. The study doctor will talk with participants about which medications they are allowed to take in this study.

Frequently Asked Questions

Will participants benefit from this study?
It is possible study participants could receive some benefit, but that is not guaranteed. However, information gathered in this study may help people in the future with negative schizophrenia symptoms.

What are the risks related to this study?
It is possible participants could experience one or more side effects during this study. The study staff will talk with all participants about any potential study-related risks and side effects.

Because research studies can affect participants’ health, all participants will be closely monitored. Researchers for this study designed a protocol, which explains the study in detail.

An independent review board responsible for participant safety has reviewed this protocol. The board also requires that the protocol be followed exactly as written.

Is study participation required?
No, participation in this study is not required.

Potential participants can talk with the study doctor about this study and other treatment options before deciding to enroll in this study. The study doctor will also discuss the risks and benefits related to other treatment options.

Additionally, enrolled study participants may stop their participation at any time and for any reason.

Who is eligible to participate in this study?
To find out if you or someone you know may qualify for participation, click below to answer a brief questionnaire. 

Who Qualifies For The Study?

To find out if you or someone you know meets initial eligibility requirements for study participation, click here to answer a few questions.

After answering the questions, you will learn if you or someone you know pre-qualifies for study participation.

If you or someone you know pre-qualifies, you will be given a list of the study centers nearest you. You may select a study center to set up a screening appointment to further determine eligibility for this study.

About Research Studies

Research studies are different than regular medical care because the purpose of research studies is to gather information about an investigational drug.

Pharmaceutical companies use research studies to evaluate an investigational drug’s safety and effectiveness.

Using the information collected in research studies, doctors and regulatory agencies can determine if an investigational drug for a specific condition could one day be made available to the public.

In order to conduct research studies, doctors need volunteers to participate. Through participation in this study, you or someone you know could help advance negative symptoms of schizophrenia research

Key Eligibility Criteria

To pre-qualify for this study, someone you know must:
  • Be 18 to 60 years of age
  • Have had onset of symptoms of schizophrenia for at least 1 year and been clinically stable for at least 6 months
  • Be taking antipsychotic medication
  • Have experienced negative symptoms for at least 6 months
  • Have a reliable informant who can answer questions about him or her Additional criteria will be assessed by the study doctor.
All study-related visits, tests, and drugs will be provided at no cost. In addition, compensation for completed study visits may be provided.

Am I Eligible For The Study?

To learn if you could be eligible for the study, please fill out the form below.